Products: Glycan Analysis Tools using Lectin Microarrays
Glycosylation is a common posttranslational modification of proteins where glycan chains are added to a protein molecule. Most of proteins are glycosylated resulting in changes in the protein such as folding, targeting, ligand recognition, binding, stability, immunogenicity, biological activity, etc.
Today, glycans play a significant biological role in four major medical areas; cancer, immunological disease, infectious disease and regenerative medicine. Glycoproteins show promise in the area of cancer biomarkers. Approximately 50% of current cancer markers widely used in clinical cancer diagnosis, are, in fact, various types of Glyco-markers. It is common knowledge in the infectious disease community that most communicable viruses target receptor glycoproteins formed on cell membranes. This fact provides drug developers with opportunities to develop vaccines directed at these target glycoproteins. These are only a few of the many examples that illustrate the need for a quick, simple and highly sensitive method for profiling and analyzing complex glycan structures which can then be used by the biopharmaceutical industry to accelerate the development of advanced biomarkers, thereapeutic proteins and stem cell (iPS, ES, and MSC) characterization methodologies; all leading to improved diagnostics and therapeutic treatments.
Based on this market need, GPB developed a novel, high throughput and highly sensitive glycan profiling instrument based on the principle of evanescent-field fluorescence excitation in combination with lectin microarrays.
Culture Media for Mesenchymal Stem Cells and EC cells
There are four kinds of Culture Media. We can deal with your order from a bottle, of which volume is 250mL. Growth factors, antibiotics and serum (10%) are contained in these culture media, so that you can use these as is.
| Products Name | Designed for | Price (in Japanese Yen) |
|---|---|---|
| Poweredby10 | Mesenchymal Stem Cells DMEM | 22,000 JPY |
| 001Plusoid-M | Mesenchymal Stem Cells MSCBM | 33,000 JPY |
| G031101 | EC Cells | 16,800 JPY |
| M061101 | Mesenchymal Stem Cells | 18,500 JPY |
Shipping Schedule: Deliver by Thursday as ordered by the last Thursday
Lifetime: One month
Shipping and Storage Condition: cold storage, avoid freezing
Remarks) Freight fee is not included in the price.
These are recommended products by RIKEN-BRC and National Institute of Biomedical Innovation.
GlycoStation™ Reader 1200, Evanescent-field Fluorescence Excitation Glycan Profiler
GlycoStation™ Reader 1200 is an ultra-high speed and highly sensitive optical microarray scanner utilizing the principle of evanescent-field fluorescence excitation to scan an entire microarray slide in only two minutes. GlycoStation™ Reader 1200 is designed to interface with a novel glycan profiling analysis system that evaluates even weak molecular interactions from a wash free lectin microarray thereby reducing the total time required to scan, profile and analyze a biological sample.
LecChip™ Ver. 1.0 Lectin Microarrays
The LecChip™ Ver 1.0 lectin microarrays contain 45 lectins, carefully selected from a candidate pool of 167 lectins. Lectins are well known as glycan recognizers and are classified into several categories, for instance; fucose, sialic acid, asialo-form, agalacto-form, high mannose, O-glycan and branching structure recognizers among others. Lectin microarrays are very effective to figure out biological glycan images, i.e. glycan epitope images, easily and with high sensitivity.
LecChip™ Ver 1.0 microarrays feature 7 wells on a glass slide with 45 lectins in each well. Each lectin is spotted 3 times resulting in a total of 135 spots, excluding position markers, in each well (45 lectins × 3 spots = 135 spots)
The lifetime of LecChip™ was extended from 3 months to 6 months with our continuous improvement activity (Jan., 2010).
Differential Glycan Profiling Analysis Software:GlycoStation™ ToolsPro Suite ver.1.5
GlycoStation™ ToolsPro Suite ver.1.5 is an integrated glycan profiling analysis software which covers all of the necessary functions starting from digitizing fluorescence patterns and ending upto the function of differential profiling.
ToolsPro Suite consists of a signal capture software named "Signal Capture ver1.1" used to digitize fluorescence patterns and a graphical analysis software named "ToolsPro ver1.5" used to compare glycan profiling patterns among samples differentially. ToolsPro contains drawing functions of glycan profiling patterns and binding curves for each lectin as well as a data export function for other applications such as NIA Array Analysis as standard features. An automatic dynamic range expansion function and an interpretation assisting function which shows glycan binding specificities grafically for each lectin are also impremented in ToolsPro.
Reagent optimized for LecChip™ Probing Solution
In order to maximize the S/N ratios of the glycan profiling patterns, GP Biosciences highly recommends the use of our proprietary probing solution for the lectin microarrays.
This solution is not only for the preparation of sample solutions but also for washing the LecChip to clean the surface. Please refer to our standard experimental protocol.
Enrichment Device
This is an automated enrichment device which is able to enrich glyco-biomarkers from serum etc.
Fully automated processing system designed for enriching target glyco-biomarkers from serum etc. using antibodies and/or lectins. This system is designed for manupulating both magnetic beads and columns, and is compatible with 96MTP. It is possible to enrich 96 samples automatically in 4 hours with this system.
Contract Analysis Service
We can also do contract analysis services with receiving your samples. Please visit Contract Analysis Session to know this service in detail.
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